MS7829
MS7829 is a cGAS inhibitor-based deubiquitinase-targeted chimera (DUBTAC), a targeted protein stabilization (TPS) technology. cGAS is a key component in the cGAS-STING pathway.[1].
Product Specifications
CAS Number
3060519-67-4
UNSPSC
12352211
Target
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms7829.html
Smiles
ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CC(NCCCCCCCCCNC(CCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl
Molecular Formula
C44H57Cl2N9O6S
Molecular Weight
910.95
References & Citations
[1]Deng Z, et al. The First-In-Class Deubiquitinase-Targeting Chimera Stabilizes and Activates cGAS. Angew Chem Int Ed Engl. 2024 Aug 16:e202415168.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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