ProMMP-9 inhibitor-3c
ProMMP-9 inhibitor-3c (compound 3c) is a potent proMMP-9 inhibitor. proMMP-9 inhibitor-3c is specific for binding to the proMMP-9 hemopexin-like domain (Kd=320 nM) . proMMP-9 inhibitor-3c disruption of MMP-9 homodimerization prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR. This disruption results in decreased phosphorylation of Src and its downstream target proteins focal adhesion kinase (FAK) and paxillin (PAX) [1].
Product Specifications
CAS Number
2138321-18-1
UNSPSC
12352005
Target
FAK; MMP; Src
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prommp-9-inhibitor-3c.html
Smiles
O=C(NC1=CC=C(F)C=C1)CCCSC(N2)=NC3=C(CCCC3)C2=O
Molecular Formula
C18H20FN3O2S
Molecular Weight
361.43
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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