Busulfan-d8

Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

Product Specifications

CAS Number

[116653-28-2]

UNSPSC

12352100

Hazard Statement

H301, H310+H330, H350

Target

Apoptosis; DNA Alkylator/Crosslinker

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Purity

99.73

Solubility

10 mM in DMSO|DMF : ≥ 16.7mg/mL|DMSO : ≥ 16.7mg/mL

Smiles

CS(=O)(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])OS(C)(=O)=O)=O

Molecular Formula

C6H6D8O6S2

Molecular Weight

254.35

Precautions

H301, H310+H330, H350

References & Citations

[1]Virginia Probin, et al. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42 (12) :1858-65.|[2]Mattan Levi, et al. Treosulfan induces distinctive gonadal toxicity compared with busulfan. Oncotarget. 2018 Apr 10;9 (27) :19317-19327.|[3]Janka Reimer, et al. Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis. Eur J Clin Pharmacol. 2012 Jun;68 (6) :923-35.