(S, S) -Sinogliatin
(S, S) -Sinogliatin ((S, S) -HMS-5552) is the (S, S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes[1].
Product Specifications
CAS Number
1191996-10-7
Product Name Alternative
(S, S) -HMS-5552; (S, S) -RO-5305552
UNSPSC
12352005
Target
Glucokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s-s-sinogliatin.html
Smiles
CC(C[C@@H](C(NC1=NN(C=C1)C[C@@H](CO)O)=O)N2CC(OC3=CC=CC=C3Cl)=CC2=O)C
Molecular Formula
C22H27ClN4O5
Molecular Weight
462.93
References & Citations
[1]Song L, et al. Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration-Mean Residence Time Methods: Mechanistic Understanding of its Pharmacokinetics. Clin Pharmacokinet. 2018 Oct;57 (10) :1307-1323.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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