MK-0668 (mesylate)
MK-0668 mesylate is an amino acid-based, potent antagonist of unactivated VLA-4, with an IC50) of 0.13 nM in human whole blood. And MK-0668 mesylate exhibits IC50s of 0.19 nM in dogs, 0.21 nM in rhesus monkeys, and 0.4 nM in rats[1].
Product Specifications
CAS Number
865111-04-2
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mk-0668-mesylate.html
Smiles
O=C([C@@H](NC([C@H]1N(C[C@@H](C1)NC2CCC2)S(=O)(C3=CC=CC(C#N)=C3)=O)=O)CC4=CC=C(C=C4)NC(C5=C(C=NC=C5Cl)Cl)=O)O.CS(=O)(O)=O
Molecular Formula
C32H34Cl2N6O9S2
Molecular Weight
781.68
References & Citations
[1]Discovery of N-{N-[ (3-Cyanophenyl) sulfonyl]-4 (R) -cyclobutylamino- (l) -prolyl}-4-[ (3′,5′-dichloroisonicotinoyl) amino]- (l) -phenylalanine (MK-0668), an Extremely Potent and Orally Active Antagonist of Very Late Antigen-4
 J. Med. Chem., 2009, 52 (11), pp 3449-3452
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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