NCATS-SM4420
NCATS-SM4420 (Compound A35) is an orally active thyroid-stimulating hormone receptor (TSHR) ligand that inhibits the proliferation of MDA-T32 and MDA-T85 cells in vitro (IC50 values of 0.71 μM and 0.38 μM, respectively) and suppresses metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds promise for research in the field of thyroid cancer[1].
Product Specifications
CAS Number
1352286-61-3
UNSPSC
12352005
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ncats-sm4420.html
Smiles
O=C(C)NC1=CC=C(C=C1)OCC2=C(OC)C=CC(C3=NC4=C(C(N3CC5=CC=CC=C5)=O)C(O)=CC=C4)=C2
Molecular Formula
C31H27N3O5
Molecular Weight
521.56
References & Citations
[1]Sarkar R, et al. An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers. J Clin Endocrinol Metab. 2024 Aug 13;109 (9) :2306-2316.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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