ERCC1/XPA interaction inhibitor 1
ERCC1/XPA interaction inhibitor 1 (compound 27o) is a potent ERCC1/XPA67-80 interaction inhibitor with an EC50 value of 4.7 µM. ERCC1/XPA interaction inhibitor 1 has the potential for the research of DNA damaging agents and overcoming resistance to platinum-based chemotherapy[1].
Product Specifications
CAS Number
3078058-57-5
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ercc1-xpa-interaction-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC=C1C(O)CSC2=NC(C)=CC(C)=C2C#N)CC3=CC=C(Cl)C=C3
Molecular Formula
C24H22ClN3O2S
Molecular Weight
451.97
References & Citations
[1]Obermann R, et al. Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. C ChemMedChem. 2024 Apr 16;19 (8) :e202300648.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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