YM-543
Product Specifications
UNSPSC Description
YM-543 is a selective SGLT2 inhibitor that effectively reduces hyperglycemia in type 2 diabetic mice through increased urinary glucose excretion. YM-543 demonstrates potent inhibition of both mouse and human SGLT2 activities at nanomolar concentrations. YM-543, when administered orally, significantly improves glucose tolerance in diabetic models and sustains its effects for over 12 hours. YM-543, in combination with other antidiabetic agents like rosiglitazone or metformin, enhances the therapeutic effects on diabetic symptoms. YM-543 does not affect blood glucose levels in normal mice, indicating its specificity for diabetic conditions.
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ym-543.html
Smiles
C[N+](C)(C)CC[O-].O[C@H]1[C@H](C2=CC(CC3=CC4=CC=CC=CC4=C3)=CC=C2O)O[C@@H]([C@H]([C@@H]1O)O)CO
Molecular Weight
499.60
References & Citations
[1]Pharmacological Characterization of YM543, a Newly Synthesized, Orally Active SGLT2 Selective Inhibitor
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125327/YM-543-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125327/
Clinical Information
Phase 2
CAS Number
1610007-47-0
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