Acifran

Acifran (AY 25712), an antihyperlipidemic agent, is an orally active agonist of GPR109A (HM74A) and GPR109B, the high and low affinity receptors for Niacin[1][2].

Product Specifications

CAS Number

[72420-38-3]

Product Name Alternative

AY 25712

UNSPSC

12352005

Target

GPR109A

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/acifran.html

Purity

99.25

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C(OC1(C)C2=CC=CC=C2)=CC1=O)O

Molecular Formula

C12H10O4

Molecular Weight

218.21

References & Citations

[1]M N Cayen, et al. The metabolic disposition of acifran, a new antihyperlipidemic agent, in rats and dogs. Xenobiotica. 1986 Mar;16 (3) :251-63. |[2]Jae-Kyu Jung, et al. Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem. 2007 Apr 5;50 (7) :1445-8.