Cycloartenyl ferulate

Cycloartenyl ferulate (Cycloartenol ferulate; Cycloartenol ferulic acid ester) is a derivative of γ-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNγR1 (binding affinity Kd = 0.5 μM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ) -triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNγ. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention[1][2][3].

Product Specifications

CAS Number

[21238-33-5]

Product Name Alternative

Cycloartenol ferulate; Cycloartenol ferulic acid ester

UNSPSC

12352005

Target

Apoptosis; Drug Derivative; JAK; Reactive Oxygen Species (ROS) ; STAT

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cycloartenyl-ferulate.html

Purity

98.98

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@@](CC2)([H])[C@H](C)CC/C=C(C)\C)C)[C@@]5([C@](CC3)([H])C(C)([C@H](CC5)OC(/C=C/C6=CC(OC)=C(C=C6)O)=O)C)C4

Molecular Formula

C40H58O4

Molecular Weight

602.89

References & Citations

[1]Guang-Liang Hong, et al. The reversal of paraquat-induced mitochondria-mediated apoptosis by cycloartenyl ferulate, the important role of Nrf2 pathway. Exp Cell Res. 2013 Nov 1;319 (18) :2845-55.|[2]T Oka, et al. Cycloartenyl ferulate, a component of rice bran oil-derived gamma-oryzanol, attenuates mast cell degranulation.Phytomedicine. 2010 Feb;17 (2) :152-6.|[3]Li M, et al. Cycloartenyl ferulate improves natural killer (NK) cell immunity against cancer by binding to IFNγ receptor 1. J Biol Chem. 2023 Aug;299 (8) :104990.