TGR5 agonist 6
TGR5 agonist 6 (compund 22b) is a non-systemic gut-targeted TGR5 agonist with significant and sustained blood sugar-lowering effects and an acceptable safety profile[1].
Product Specifications
CAS Number
[2925211-47-6]
UNSPSC
12352005
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tgr5-agonist-6.html
Smiles
O=C(N1CCCCCC(NCCCCCCNC(CCC(C=C2Cl)=C(C=C2OC3=C(C=NC=C3)C(N4CCN(C5=C4C=CC=C5)C6CC6)=O)Cl)=O)=O)C=CC1=O
Molecular Formula
C42H48Cl2N6O6
Molecular Weight
803.77
References & Citations
[1]Zhao S, et al. Design, Synthesis, and Biological Evaluation of Covalently Mucoadhesive Derivatives as Nonsystemic Intestine-Targeted TGR5 Agonists. J Med Chem. 2024 Oct 10;67 (19) :17701-17712.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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