TGR5 agonist 6

TGR5 agonist 6 (compund 22b) is a non-systemic gut-targeted TGR5 agonist with significant and sustained blood sugar-lowering effects and an acceptable safety profile[1].

Product Specifications

CAS Number

[2925211-47-6]

UNSPSC

12352005

Target

G protein-coupled Bile Acid Receptor 1

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tgr5-agonist-6.html

Smiles

O=C(N1CCCCCC(NCCCCCCNC(CCC(C=C2Cl)=C(C=C2OC3=C(C=NC=C3)C(N4CCN(C5=C4C=CC=C5)C6CC6)=O)Cl)=O)=O)C=CC1=O

Molecular Formula

C42H48Cl2N6O6

Molecular Weight

803.77

References & Citations

[1]Zhao S, et al. Design, Synthesis, and Biological Evaluation of Covalently Mucoadhesive Derivatives as Nonsystemic Intestine-Targeted TGR5 Agonists. J Med Chem. 2024 Oct 10;67 (19) :17701-17712.