Recombinant Human Pleiotrophin (PTN) Protein

<strong>Recombinant Human Pleiotrophin (PTN) Protein</strong>_x000D_ <strong>Catalog number:</strong> B2015889_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 20 kDa, monomer, non-glycosylated_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> HARP, HB GAM, HBBM, HBGF 8, HBGF8, HBNF, HBNF 1, HBNF1, Heparin binding brain mitogen, NEGF1, OSF 1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss Nat Neurosci. 2019 Jul;22(7):1089-1098._x000D_ 2: Bernard-Pierrot I, Héroult M, Lemaître G, Barritault D, Courty J, Milhiet PE. Glycosaminoglycans promote HARP/PTN dimerization Biochem Biophys Res Commun. 1999 Dec 20;266(2):437-42._x000D_ 3: Schulte AM, Malerczyk C, Cabal-Manzano R, Gajarsa JJ, List HJ, Riegel AT, Wellstein A. Influence of the human endogenous retrovirus-like element HERV-E.PTN on the expression of growth factor pleiotrophin: a critical role of a retroviral Sp1-binding site Oncogene. 2000 Aug 17;19(35):3988-98._x000D_ 4: Murasugi A, Kido I, Kumai H, Asami Y. Efficient production of recombinant human pleiotrophin in yeast, Pichia pastoris Biosci Biotechnol Biochem. 2003 Oct;67(10):2288-90._x000D_ 5: Zhang L, Xia D, Wang C, Gao F, Hu L, Li J, Jin L. Pleiotrophin attenuates the senescence of dental pulp stem cells Oral Dis. 2023 Jan;29(1):195-205._x000D_ 6: Jin L, Gao F, Zhang L, Wang C, Hu L, Fan Z, Xia D. Pleiotropin enhances the osteo/dentinogenic differentiation potential of dental pulp stem cells Connect Tissue Res. 2021 Sep;62(5):495-507._x000D_ 7: Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, Gadhavi J, Lolo K, Trejo-Lopez J, Phillips JL, Iturbe A, Erqiuzi A, Moore BD, Ryu D, Natu A, Dillon KD, Torrellas J, Moran C, Ladd TB, Afroz KF, Islam T, Jagirdar J, Funk CC, Robinson M, Borchelt DR, Ertekin-Taner N, Kelly JW, Heppner FL, Johnson EC, McFarland K, Levey AL, Prokop S, Seyfried NT, Golde TE. Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease bioRxiv [Preprint]. 2023 Dec 7:2023.11.29.568318._x000D_ 8: Tsirmoula S, Dimas K, Hatziapostolou M, Lamprou M, Ravazoula P, Papadimitriou E. Implications of pleiotrophin in human PC3 prostate cancer cell growth in vivo Cancer Sci. 2012 Oct;103(10):1826-32._x000D_ 9: Singh PK, Srivastava V. Recombinant expression and purification of heparin binding proteins: midkine and pleiotrophin from Escherichia coli Protein Expr Purif. 2012 Oct;85(2):181-6._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/25617851">10: Zhu X, Bai Y, Yu W, Pan C, Jin E, Song D, Xu Q, Yao Y, Huang L, Tao Y, Li X, Zhao M. The effects of pleiotrophin in proliferative diabetic retinopathy PLoS One. 2015 Jan 24;10(1):e0115523. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant Human Pleiotrophin (PTN) Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>