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PXS-4728A

PXS-4728A (BI-1467335) is a potent and orally active semicarbazide-sensitive amine oxidase (SSAO) inhibitor. PXS-4728A inhibits airway inflammation. PXS-4728A has the potential for the research of chronic obstructive pulmonary disease (COPD) [1].

Product Specifications

CAS Number

[1478364-68-9]

Product Name Alternative

BI-1467335

UNSPSC

12352005

Hazard Statement

H302, H361, H373

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pxs-4728a.html

Purity

98.79

Solubility

DMSO : 233.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(NC(C)(C)C)C1=CC=C(OC/C(CN)=C/F)C=C1.Cl

Molecular Formula

C15H22ClFN2O2

Molecular Weight

316.80

Precautions

H302, H361, H373

References & Citations

[1]A G Jarnicki, et al. The Inhibitor of Semicarbazide-Sensitive Amine Oxidase, PXS-4728A, Ameliorates Key Features of Chronic Obstructive Pulmonary Disease in a Mouse Model. Br J Pharmacol. 2016 Nov;173 (22) :3161-3175.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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