SIM-6080

SIM-6080 is a calcium antagonist and inhibits the proliferation of rat aortic myocytes and reduces aortic atherosclerosis in rabbits[1][2].

Product Specifications

CAS Number

118790-68-4

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sim-6080.html

Smiles

FC1=CC=C(C(CCN(CCN(CC2=CC(OC)=C(C(OC)=C2)OC)C)C)C3=CC=C(C=C3)F)C=C1

Molecular Formula

C29H36F2N2O3

Molecular Weight

498.60

References & Citations

[1]Bernini F, et al. In vitro inhibition of arterial myocyte growth and stimulation of low density lipoprotein metabolism by SIM 6080, a new calcium antagonist. Pharmacol Res. 1990;22 (1) :27-35. |[2]Maggi FM, et al. SIM 6080, a new calcium antagonist, reduces aortic atherosclerosis in cholesterol-fed rabbits. Pharmacol Res. 1993;28 (3) :219-227.