Glutaminyl cyclases-IN-1
Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC50 values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages[1].
Product Specifications
CAS Number
3032400-33-9
Product Name Alternative
IsoQC-IN-1
UNSPSC
12352005
Target
CD47
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/glutaminyl-cyclases-in-1.html
Purity
98.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(C=CC(CN2C=NC3=CC(C4=NN=C(S4)N)=CC=C32)=C1)OCCCN5CCCCC5
Molecular Formula
C25H30N6O2S
Molecular Weight
478.61
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Mucin 5AC (MUC5AC) (45M1), CF640R conjugate, 0.1mg/mL
CD44 Standard (DF1485), CF647 conjugate, 0.1mg/mL
Pmel17 / gp100 / SILV (NKI-beteb), CF740 conjugate, 0.1mg/mL
CD45 / LCA (2B11 + PD7/26), CF740 conjugate, 0.1mg/mL
