Glutaminyl cyclases-IN-1

Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC50 values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages[1].

Product Specifications

CAS Number

[3032400-33-9]

Product Name Alternative

IsoQC-IN-1

UNSPSC

12352005

Target

CD47

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/glutaminyl-cyclases-in-1.html

Purity

98.21

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(C=CC(CN2C=NC3=CC(C4=NN=C(S4)N)=CC=C32)=C1)OCCCN5CCCCC5

Molecular Formula

C25H30N6O2S

Molecular Weight

478.61

References & Citations

[1]Eunsun Park, et al. 2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint. ACS Med. Chem. Lett. 2022.