RK-682 (hemicalcium)
RK-682 hemicalcium is the hemicalcium salt form of RK-682 (HY-135564A) . RK-682 hemicalcium is the inhibitor for protein tyrosine phosphatase (PTPase), heparanase, phospholipase A2 and HIV-1 protease. RK-682 hemicalcium inhibits the dephosphorylation of CD45 (IC50 is 54 μM) and VHR (IC50 is 2.0 μM), and thereby inhibits the ERK signaling pathway. RK-682 hemicalcium inhibits the cell viability of cancer cell MGH-U3, T24 and UROtsa with IC50s of 78.2, 43.2 and 145 nM, respectively, arrests the cell cycle at G1/S phase, inhibits the cell migration and autophagy in MGH-U3 and T24[1][2][3].
Product Specifications
CAS Number
[332131-32-5]
UNSPSC
12352005
Target
Autophagy; ERK; HIV Protease; Phosphatase; Phospholipase
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/rk-682-hemicalcium.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCCCCCCC(C1=C([C@@H](CO)OC1=O)O)=O.[1/2].[Ca]
Molecular Formula
C21H36O5.1/2Ca
Molecular Weight
408.59
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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