Selexipag

Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor) .

Product Specifications

CAS Number

[475086-01-2]

Product Name Alternative

NS-304; ACT-293987

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/NS-304.html

Concentration

10mM

Purity

99.86

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(NS(=O)(C)=O)COCCCCN(C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)N=C1)C(C)C

Molecular Formula

C26H32N4O4S

Molecular Weight

496.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Kuwano K, et al. 2-[4-[ (5,6-diphenylpyrazin-2-yl) (isopropyl) amino]butoxy]-N- (methylsulfonyl) acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J Pharmacol Exp Ther. 2007 Sep;322 (3) :1181-8.|[2]Mous DS, et al. Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag's active compound, at the pseudoglandular stage improves lung vasculature. Am J Physiol Lung Cell Mol Physiol. 2018 May 10.