HJC0416 (hydrochloride)

HJC0416 hydrochloride is a potent and orally active STAT3 inhibitor with an enhanced anticancer profile than Stattic (HY-13818) . HJC0416 hydrochloride is a promising anti-cancer agent for breast cancer study[1].

Product Specifications

CAS Number

[2415263-08-8]

UNSPSC

12352005

Target

Apoptosis; STAT

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hjc0416-hydrochloride.html

Purity

98.68

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C=CS2(=O)=O)C2=C1)C3=CC(Cl)=CC=C3OCCCN.[H]Cl

Molecular Formula

C18H18Cl2N2O4S

Molecular Weight

429.32

References & Citations

[1]Haijun Chen, et al.Discovery of Potent Anticancer Agent HJC0416, an Orally Bioavailable Small Molecule Inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3) . Eur J Med Chem. 2014 Jul 23;82:195-203.