Orotic acid (potassium)
Product Specifications
UNSPSC Description
Orotic acid potassium (Vitamin B13 potassium) is a precursor of pyrimidine bases and is involved in the synthesis of DNA and RNA. Orotic acid potassium stimulates the growth of animals, plants and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. Orotic acid potassium is a measurement indicator in routine newborn screening for urea cycle abnormalities. Orotic acid potassium can cause hepatic steatosis and hepatomegaly in rats[1][2][3][4].
Target Antigen
DNA/RNA Synthesis; Endogenous Metabolite
Type
Biochemical Assay Reagents
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/orotic-acid-potassium.html
Purity
99.51
Solubility
H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C(NC1=O)=CC(N1)=O)O[K]
Molecular Weight
194.19
References & Citations
[1]Löffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids.|[2]Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15.|[3]Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110(4):816-21.|[4]Kochkin, et al. "Orotic acid and its derivatives. Preparation, properties, and uses." Pharmaceutical Chemistry Journal 11.8 (1977): 1155-1160.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0157C/Orotic-acid-potassium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0157C/Orotic-acid-potassium-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
24598-73-0
Available Sizes
Curated Selection
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