Orotic acid (potassium)

Orotic acid potassium (Vitamin B13 potassium) is a precursor of pyrimidine bases and is involved in the synthesis of DNA and RNA. Orotic acid potassium stimulates the growth of animals, plants and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. Orotic acid potassium is a measurement indicator in routine newborn screening for urea cycle abnormalities. Orotic acid potassium can cause hepatic steatosis and hepatomegaly in rats[1][2][3][4].

Product Specifications

CAS Number

[24598-73-0]

Product Name Alternative

6-Carboxyuracil (potassium) ; Vitamin B13 (potassium)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; Endogenous Metabolite

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/orotic-acid-potassium.html

Purity

99.51

Solubility

H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(NC1=O)=CC(N1)=O)O[K]

Molecular Formula

C5H3KN2O4

Molecular Weight

194.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Löffler M, et, al. Orotate (orotic acid) : An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids.|[2]Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15.|[3]Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110 (4) :816-21.|[4]Kochkin, et al. "Orotic acid and its derivatives. Preparation, properties, and uses." Pharmaceutical Chemistry Journal 11.8 (1977) : 1155-1160.