UNC2881

UNC2881 is an orally active and specific Mer kinase inhibitor, inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. UNC2881 shows additional inhibition against Axl and Tyro with IC50s of 360 nM and 250 nM, respectively. UNC2881 potently inhibits collagen-induced platelet aggregation, can be used for pathologic thrombosis research[1].

Product Specifications

CAS Number

[1493764-08-1]

UNSPSC

12352005

Hazard Statement

H302

Target

TAM Receptor; VSV

Type

Reference compound

Related Pathways

Anti-infection; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/UNC2881.html

Purity

99.79

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCNC1=NC(N[C@H]2CC[C@H](O)CC2)=C(C(NCC3=CC=C(N4C=NC=C4)C=C3)=O)C=N1

Molecular Formula

C25H33N7O2

Molecular Weight

463.58

Precautions

H302

References & Citations

[1]Zhang W, et al. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013 Dec 12;56 (23) :9693-700.|[2]Tom Adomati, et al. Dead Cells Induce Innate Anergy Via Mertk after Acute Viral Infection. Cell Reports. 2020. 30 (11) :3671-3681.