UNC2881
Product Specifications
UNSPSC Description
UNC2881 is an orally active and specific Mer kinase inhibitor, inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. UNC2881 shows additional inhibition against Axl and Tyro with IC50s of 360 nM and 250 nM, respectively. UNC2881 potently inhibits collagen-induced platelet aggregation, can be used for pathologic thrombosis research[1].
Target Antigen
TAM Receptor; VSV
Type
Reference compound
Related Pathways
Anti-infection;Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/UNC2881.html
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CCCCNC1=NC(N[C@H]2CC[C@H](O)CC2)=C(C(NCC3=CC=C(N4C=NC=C4)C=C3)=O)C=N1
Molecular Weight
463.58
References & Citations
[1]Zhang W, et al. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013 Dec 12;56(23):9693-700.|[2]Tom Adomati, et al. Dead Cells Induce Innate Anergy Via Mertk after Acute Viral Infection. Cell Reports. 2020. 30(11):3671-3681.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15798/UNC2881-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15798/UNC2881-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1493764-08-1
Available Sizes
Curated Selection
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