Sparstolonin B
Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[1][2].
Product Specifications
CAS Number
1259330-61-4
UNSPSC
12352005
Hazard Statement
H315, H319
Target
HIV; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sparstolonin-b.html
Purity
99.94
Smiles
O=C1OC=C2C3=C(OC4=C2C1=C(O)C=C4)C=CC(O)=C3
Molecular Formula
C15H8O5
Molecular Weight
268.22
Precautions
H315, H319
References & Citations
[1]Liang Q, et al. Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. J Biol Chem. 2011;286 (30) :26470-26479.|[2]Deng X, et al. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription. Virol J. 2015;12:108. Published 2015 Jul 25.|[3]Kumar A, et al. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells [published correction appears in PLoS One. 2016;11 (7) :e0159082]. PLoS One. 2014;9 (5) :e96343. Published 2014 May 1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1; TLR2; TLR4
Available Sizes
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