Sparstolonin B

Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[1][2].

Product Specifications

CAS Number

[1259330-61-4]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

HIV; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sparstolonin-b.html

Purity

99.94

Smiles

O=C1OC=C2C3=C(OC4=C2C1=C(O)C=C4)C=CC(O)=C3

Molecular Formula

C15H8O5

Molecular Weight

268.22

Precautions

H315, H319

References & Citations

[1]Liang Q, et al. Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. J Biol Chem. 2011;286 (30) :26470-26479.|[2]Deng X, et al. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription. Virol J. 2015;12:108. Published 2015 Jul 25.|[3]Kumar A, et al. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells [published correction appears in PLoS One. 2016;11 (7) :e0159082]. PLoS One. 2014;9 (5) :e96343. Published 2014 May 1.