Nav1.7-IN-18
Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, showing analgesic effects in transgenic mice with inherited erythromelalgia (IEM) [1].
Product Specifications
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nav1-7-in-18.html
Smiles
C[C@H]1[C@H](C[C@H]([C@@H]1C(O)=O)C(C2=C(C=C(C(C3CC3)=C2)OCC4CCN(CC4)CC5=C(C=CC=C5Cl)Cl)F)=O)F
Molecular Formula
C30H33Cl2F2NO4
Molecular Weight
580.49
References & Citations
[1]Shaoyi Sun, et al. Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7. Bioorg Med Chem Lett. 2025 Feb 1:116:130033.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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