Bcl-2/Mcl-1-IN-4
Bcl-2/Mcl-1-IN-4 (compound 20) is a dual inhibitor targeting Bcl-2 (Ki=0.49 μM) and Mcl-1 (Ki=0.51 μM) . Bcl-2/Mcl-1-IN-4 significantly inhibits cancer cell proliferation and effectively induces apoptosis in U937 cells. Bcl-2/Mcl-1-IN-4 can be used in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-mcl-1-in-4.html
Smiles
O=C(NS(=O)(C1=CC=C([N+]([O-])=O)C=C1)=O)[C@@H](NC(CN2C(/C(SC2=O)=C/C3=CC=C(C4=CC=C(C)C=C4)C=C3)=O)=O)CC5=CC=C(Br)C=C5
Molecular Formula
C34H27BrN4O8S2
Molecular Weight
763.63
References & Citations
[1]Jiabing Long, et al. "Discovery and development of thiazolidine-2, 4-dione derivatives as Bcl-2/Mcl-1 dual inhibitors." Bioorganic Chemistry (2024) : 107687.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Mcl-1
Frequently Asked Questions
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