KF24345 (free base)

KF24345 free base is an orally active adenosine uptake inhibitor. KF24345 free base inhibits adenosine uptake by human, mouse, rabbit and hamster erythrocytes with IC50 values of 59.5, 130.1, 104.2 and 30.9 nM, respectively. KF24345 free base has anti-inflammatory activity and can inhibit LPS-induced TNF-α production and leukopenia in mice[1].

Product Specifications

CAS Number

[178750-21-5]

UNSPSC

12352005

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kf24345-free-base.html

Smiles

O=C(N(C1=C(C2=O)C=C(C=C1)C)C)N2C3CCN(CC3)C4=C5C=C(C(OCC)=CC5=NC(N6CCOCC6)=N4)OCC

Molecular Formula

C31H38N6O5

Molecular Weight

574.67

References & Citations

[1]Noji T, et al. KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-α production and leukopenia via endogenous adenosine in mice[J]. Journal of Pharmacology and Experimental Therapeutics, 2002, 300 (1) : 200-205.