VIP236
VIP236 is a small-molecule-drug conjugates (SMDCs) consisting of an αvβ3 integrin binder linked to an optimized Camptothecin topoisomerase I (TOP1) inhibitor payload. VIP236 exerts anticancer activity by targeting αvβ3 integrins, and it can release payload upon cleavage by neutrophil elastase in the tumor microenvironment[1].
Product Specifications
CAS Number
2418533-90-9
UNSPSC
12352005
Target
Elastase; Integrin
Type
Reference compound
Related Pathways
Cytoskeleton; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vip236.html
Smiles
O=C(O[Na])C[C@@H](NC(NC1=CC=C(NC(NCCOCCOCCOCCC(N[C@H](C(N2[C@H](C(N[C@@H](C(C)C)C(O[C@@](C(OC3)=O)(CC)C4=C3C(N(CC5=C(CC)C(C=CC=C6)=C6N=C57)C7=C4)=O)=O)=O)CCC2)=O)CC(O[Na])=O)=O)=O)C=C1)=O)C8=CC=CC(NS(C9=CC=CC(NC(NCCC)=O)=C9)(=O)=O)=C8
Molecular Formula
C72H84N12Na2O20S
Molecular Weight
1515.55
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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