DB008

DB008 is potent and selective PARP16 inhibitor with an IC50 value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively[1]. DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2991637-98-8]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/db008.html

Concentration

10mM

Purity

98.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(C=C)=O)CC3)=O)=C2)C4=C1C=CC(C#C)=C4

Molecular Formula

C25H21FN4O3

Molecular Weight

444.46

References & Citations

[1]Bejan DS, et, al. Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor. Chem Sci. 2022 Nov 16;13 (46) :13898-13906.