P-Cresyl sulfate

P-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT) . p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways[1][2][3].

Product Specifications

CAS Number

[3233-58-7]

Product Name Alternative

P-Tolyl sulfate

UNSPSC

12352005

Hazard Statement

H302, H314, H335

Target

JNK; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/p-Cresyl_Sulfate.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=S(OC1=CC=C(C)C=C1)(O)=O

Molecular Formula

C7H8O4S

Molecular Weight

188.20

Precautions

H302, H314, H335

References & Citations

[1]Wu TK, et al. The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal cell carcinoma via microRNA-21/ HIF-1α axis signals. Sci Rep. 2019 Mar 1;9 (1) :3207.|[2]Koppe L, et al. p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013 Jan;24 (1) :88-99.|[3]Tanaka H, et al. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct;56 (2) :347-54.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite; Microbial Metabolite

Citation 01

Cell Death Dis. 2023 Feb 2;14 (2) :78.|Phytomedicine. 2024 Oct 28:135:156174.|ACS Appl Bio Mater. 2024 Jun 17;7 (6) :3841-3853.|Cell Metab. 2024 Jun 18:S1550-4131 (24) 00189-X.|Colloids Surf B Biointerfaces. 2024 Aug 13:244:114164.|Electrochim Acta. 2025 Oct 26.