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Naproxen Gilteritinib

Naproxen Gilteritinib is the active reference substance of Gilteritinib (HY-12432) . Gilteritinib is the target protein ligand of PROTAC degrader LWY713 (HY-157213) [1].

Product Specifications

CAS Number

[1373410-40-2]

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/naproxen-gilteritinib.html

Smiles

O=C(C1=C(NC(C=C2OC)=CC=C2N3CCC(CC3)N4CCNCC4)N=C(C(CC)=N1)NC5CCOCC5)N

Molecular Formula

C28H42N8O3

Molecular Weight

538.68

References & Citations

[1]Liu W, et al., Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia. Eur J Med Chem. 2024 Jan 15;264:115974.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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