DOTAP (chloride)
Product Specifications
UNSPSC Description
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid[1].
Target Antigen
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dotap-chloride.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 130 mg/mL (ultrasonic)
Smiles
CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]
Molecular Weight
698.54
References & Citations
[1]Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes.Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):1996-2001.Adv Healthc Mater. 2022: 2202412.|Exploration. 2024 Jun 26.|Nanoscale. 2023 Nov 16;15(44):17825-17838.|Pharmaceutics. 2023 Apr 30, 15(5), 1379.|SSRN. 2024 Nov 12.|Drug Dev Ind Pharm. 2024 Aug 7:1-16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112754A/DOTAP-chloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112754A/DOTAP-chloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
132172-61-3
Available Sizes
Curated Selection
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