DOTAP (chloride)
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid[1].
Product Specifications
CAS Number
[132172-61-3]
Product Name Alternative
1,2-Dioleoyl-3-trimethylammonium-propane (chloride)
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dotap-chloride.html
Purity
99.91
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 130 mg/mL (ultrasonic)
Smiles
CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]
Molecular Formula
C42H80ClNO4
Molecular Weight
698.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes.Biochim Biophys Acta. 2015 Oct;1848 (10 Pt A) :1996-2001.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Citation 01
Adv Healthc Mater. 2023 Jan;12 (6) :e2202412.|bioRxiv. 2025 Oct 1.|Exploration. 2024 Jun 26;5 (1) :20240002.|Microbiol Spectr. 2025 Nov 5;13 (12) :e0143825.|Nanoscale. 2023 Nov 16;15 (44) :17825-17838.|Nat Immunol. 2025 Oct;26 (10) :1660-1672.|Pharmaceutics. 2023 Apr 30;15 (5) :1379.|SSRN. 2024 Nov 12.|University of Washington. 2025.|Drug Dev Ind Pharm. 2024 Aug 7:1-16.|Signal Transduct Target Ther. 2025 Mar 24;10 (1) :101.
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