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Isatin (Standard)

Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) [1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].

Product Specifications

CAS Number

91-56-5

Product Name Alternative

Indoline-2,3-dione (Standard)

UNSPSC

12352005

Target

Apoptosis; Monoamine Oxidase; Reference Standards

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling; Others

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/isatin-standard.html

Smiles

O=C1NC2=C(C=CC=C2)C1=O

Molecular Formula

C8H5NO2

Molecular Weight

147.13

References & Citations

[1]Glover V, et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry, 51 (2), 656–659.|[2]Igosheva N, et al. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug;47 (3) :216-24.|[3]McIntyre IM, et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990;79 (1-2) :35-40.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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