E28362

E28362 is a novel small molecule PCSK9 inhibitor. E28362 blocks the interaction between PCSK9 and LDLR, thereby preventing the degradation of LDLR and maintaining cholesterol homeostasia. E28362 is a promising lead compound for the study of hyperlipidemia and atherosclerosis[1].

Product Specifications

CAS Number

[930017-01-9]

UNSPSC

12352005

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/e28362.html

Purity

94.51

Smiles

O=C1NC(CN(CC(O)C)C2=O)=C2C(C3=CC=C(C)C=C3)N1

Molecular Formula

C16H19N3O3

Molecular Weight

301.34

References & Citations

[1]Wang W, et al. A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis[J]. Acta Pharmacologica Sinica, 2024: 1-15.