Aurothiomalate (sodium)

Aurothiomalate sodium is a potent and selective oncogenic PKCι signaling inhibitor. Aurothiomalate sodium inhibits tumor cell proliferation and not cell apoptosis. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium, an anti-rheumatoid agent, exhibits potent anti-tumor activity[1][2][3].

Product Specifications

CAS Number

[12244-57-4]

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aurothiomalate-sodium.html

Purity

98.0

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

OC(CC(S)C(O)=O)=O.[Na].[Au]

Molecular Formula

C4H6O4S.Au.xNa

Precautions

H302, H312, H332

References & Citations

[1]Roderick P Regala, et al. Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells. Cancer Res. 2008 Jul 15;68 (14) :5888-95.|[2]Roderick P Regala, et al. Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. Cancer Res. 2009 Oct 1;69 (19) :7603-11.|[3]Atsuko Sakurai, et al. Overexpression of thioredoxin reductase 1 regulates NF-kappa B activation. J Cell Physiol. 2004 Jan;198 (1) :22-30.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PKCι

Available Sizes

Curated Selection

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