CDK5 Substrate - (5-TMR) labeled

<strong>CDK5 Substrate - (5-TMR) labeled</strong>_x000D_ <strong>Catalog number:</strong> B2019514_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1551_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> 5-TMR-PKTPKKAKKL_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: He Y, Pan S, Xu M, He R, Huang W, Song P, Huang J, Zhang HT, Hu Y. Adeno-associated virus 9-mediated Cdk5 inhibitory peptide reverses pathologic changes and behavioral deficits in the Alzheimer's disease mouse model FASEB J. 2017 Aug;31(8):3383-3392._x000D_ 2: Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5 Neuron. 2012 Aug 23;75(4):675-87._x000D_ 3: Cho DH, Seo J, Park JH, Jo C, Choi YJ, Soh JW, Jo I. Cyclin-dependent kinase 5 phosphorylates endothelial nitric oxide synthase at serine 116 Hypertension. 2010 Feb;55(2):345-52._x000D_ 4: Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles Neuron. 2003 Oct 30;40(3):471-83._x000D_ 5: Nguyen MD, Larivière RC, Julien JP. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions Neuron. 2001 Apr;30(1):135-47._x000D_ 6: Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity Neuron. 2008 May 22;58(4):571-83._x000D_ 7: Zambrano CA, Egaña JT, Núñez MT, Maccioni RB, González-Billault C. Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1 Free Radic Biol Med. 2004 Jun 1;36(11):1393-402._x000D_ 8: Cazares VA, Njus MM, Manly A, Saldate JJ, Subramani A, Ben-Simon Y, Sutton MA, Ashery U, Stuenkel EL. Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn J Neurosci. 2016 Nov 2;36(44):11208-11222._x000D_ 9: Yeh CW, Hsu LS. Zebrafish diras1 Promoted Neurite Outgrowth in Neuro-2a Cells and Maintained Trigeminal Ganglion Neurons In Vivo via Rac1-Dependent Pathway Mol Neurobiol. 2016 Dec;53(10):6594-6607._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/24148298">10: Nehmé R, Nehmé H, Roux G, Destandau E, Claude B, Morin P. Capillary electrophoresis as a novel technique for screening natural flavonoids as kinase inhibitors J Chromatogr A. 2013 Nov 29;1318:257-64. </a>_x000D_ _x000D_ <strong>Products Related to CDK5 Substrate - (5-TMR) labeled can be found at</strong> <a href="https://moleculardepot.com/product-category/Substrates/"> Substrates</a>