Gardenin B

Gardenin B is a methoxyflavone compound and an inhibitor of USP7, ODC (IC50: 6.24 μg/mL), and Cathepsin D (IC50: 5.61 μg/mL) . Gardenin B exhibits antioxidant and antitumor activities. Gardenin B shows IC50 values of 8.87 and 10.59 μg/mL for DPPH and NO scavenging, respectively, and also possesses ferric ion reducing ability. Additionally, Gardenin B can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. Gardenin B can be used in cancer research[1][2][3].

Product Specifications

CAS Number

[2798-20-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Caspase; Cathepsin; Deubiquitinase; Ornithine decarboxylase (ODC) ; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gardenin-b.html

Purity

99.69

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C2C(OC(C3=CC=C(OC)C=C3)=CC2=O)=C(OC)C(OC)=C1OC

Molecular Formula

C19H18O7

Molecular Weight

358.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Cabrera J, et al. Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species. Chem Biol Interact. 2016 Aug 25;256:220-7.|[2]Zhang S, et al. Gardenin B, A Natural Inhibitor for USP7: In vitro Evaluation and In silico Identification. Letters in Drug Design & Discovery, 2024, 21 (12) : 2352-2358.|[3]Maurya P, et al. Characterization of bioactive constituents from the gum resin of Gardenia lucida and its pharmacological potential. Biomed Pharmacother. 2017 Jan;85:444-456.