POLA1 inhibitor 1
POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].
Product Specifications
CAS Number
[2217671-41-3]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pola1-inhibitor-1.html
Concentration
10mM
Purity
98.00
Solubility
DMSO : 180 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/C1=CC=C(C2=CC=C(O)C(C34CC5CC(C4)CC(C5)C3)=C2)C(/C=N/O)=C1
Molecular Formula
C26H27NO4
Molecular Weight
417.50
References & Citations
[1]Cincinelli R, et al. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorg Chem. 2020 Nov;104:104253.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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