Osthenol
Osthenol (Ostenol) is a reversible, selective, competitive inhibitor of hMAO-A (IC50=0.74 μM, Ki=0.26 μM), with antifungal and antibacterial activity. Osthenol inhibits the oxidative deamination of hMAO-A and regulates the metabolism of monoamine neurotransmitters. Osthenol also inhibits the PI3K/AKT signaling pathway to induce apoptosis of colon cancer cells, arrest the cell cycle at the G1 phase, and inhibit cell proliferation. Osthenol is mainly used in the study of neurological diseases and cancer, especially depression-related MAO-A targeted intervention and colon cancer[1][2][3][4].
Product Specifications
CAS Number
484-14-0
Product Name Alternative
Ostenol
UNSPSC
12352005
Target
Akt; Apoptosis; Monoamine Oxidase; PI3K
Type
Natural Products
Related Pathways
Apoptosis; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/osthenol.html
Purity
99.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=CC=C(O)C(C/C=C(C)\C)=C2O1
Molecular Formula
C14H14O3
Molecular Weight
230.26
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MAO-A
Available Sizes
Frequently Asked Questions
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