Osthenol

Osthenol (Ostenol) is a reversible, selective, competitive inhibitor of hMAO-A (IC50=0.74 μM, Ki=0.26 μM), with antifungal and antibacterial activity. Osthenol inhibits the oxidative deamination of hMAO-A and regulates the metabolism of monoamine neurotransmitters. Osthenol also inhibits the PI3K/AKT signaling pathway to induce apoptosis of colon cancer cells, arrest the cell cycle at the G1 phase, and inhibit cell proliferation. Osthenol is mainly used in the study of neurological diseases and cancer, especially depression-related MAO-A targeted intervention and colon cancer[1][2][3][4].

Product Specifications

CAS Number

[484-14-0]

Product Name Alternative

Ostenol

UNSPSC

12352005

Target

Akt; Apoptosis; Monoamine Oxidase; PI3K

Type

Natural Products

Related Pathways

Apoptosis; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/osthenol.html

Purity

99.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=CC=C(O)C(C/C=C(C)\C)=C2O1

Molecular Formula

C14H14O3

Molecular Weight

230.26

References & Citations

[1]Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019 Mar 15;29 (6) :839-843.|[2]Zhuang B, et al. Osthenol inhibits the viability of HCT116 cells through suppressing PI3K/AKT signaling pathway. Int J Clin Exp Pathol, 2017, 10 (6) : 6308-6315.|[3]Nemolochnova AG, et al. Stability Study, Quantification Method and Pharmacokinetics Investigation of a Coumarin-Monoterpene Conjugate Possessing Antiviral Properties against Respiratory Syncytial Virus. Pharmaceuticals (Basel) . 2022 Sep 18;15 (9) :1158.|[4]Cho P, et al. Characterization of osthenol metabolism in vivo and its pharmacokinetics. Xenobiotica. 2020 Jul;50 (7) :839-846.|[5]Montagner C, et al. Antifungal activity of coumarins. Z Naturforsch C J Biosci. 2008 Jan-Feb;63 (1-2) :21-8.|[6]de Souza SM, et al. Antibacterial activity of coumarins. Z Naturforsch C J Biosci. 2005 Sep-Oct;60 (9-10) :693-700.