(E/Z) -E64FC26

(E/Z) -E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].

Product Specifications

CAS Number

2285446-67-3

UNSPSC

12352005

Target

Apoptosis; PDI

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-z-e64fc26.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(/C(C=C2C(F)(F)F)=C/CCCCCCCC)C=C1O

Molecular Formula

C19H23F3O2

Molecular Weight

340.38

References & Citations

[1]Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1.|[2]Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33 (4) :1011-1022.