GnGn-bi-Asn-PABA (Highly Pure)

<strong>GnGn-bi-Asn-PABA</strong>_x000D_ <strong>Catalog number:</strong> MDP0881_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 0.1 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1578.5 g/mol_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> substrate for GDP-L-Fuc: N-Acetyl-beta-D-Glucosaminide alpha1-6Fucosyltransferase_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> O-beta-2-Acetamido-2-deoxy-D-glucopyranosyl-(1?2)-O-alpha-D-mannopyranosyl-(1?3)-[O-beta-2-acetamido-2-deoxy-D-glucopyranosyl-(1?2)-O-alpha-D-mannopyranosyl-(1?6)]-O-beta-D-mannopyranosyl-(1?4)-O-beta-2-acetamido-2-deoxy-D-glucopyranosyl-(1?4)-N-beta-2-acetamido-2-deoxy-D-glucopyranosyl-(1?4)-L-asparagine 4-(2-pyridylamino)butylamide_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ <strong>Indication for Use:</strong>This product is for Research Use Only. This product is NOT for human or animal use._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Bastian K, Scott E, Elliott DJ, Munkley J. FUT8_x000D_ Alpha-(1,6)-Fucosyltransferase in Cancer. Int J Mol Sci. 2021 Jan 5;22(1):455._x000D_ _x000D_ 2: Tada K, Ohta M, Hidano S, Watanabe K, Hirashita T, Oshima Y, Fujnaga A,_x000D_ Nakanuma H, Masuda T, Endo Y, Takeuchi Y, Iwashita Y, Kobayashi T, Inomata M._x000D_ Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of_x000D_ pancreatic ductal adenocarcinoma. Surg Today. 2020 Jul;50(7):767-777._x000D_ _x000D_ 3: Merino P, Tejero T, Delso I, Hurtado-Guerrero R, Gómez-SanJuan A, Sádaba D._x000D_ Recent progress on fucosyltransferase inhibitors. Mini Rev Med Chem. 2012_x000D_ Dec;12(14):1455-64._x000D_ _x000D_ 4: Tu Z, Lin YN, Lin CH. Development of fucosyltransferase and fucosidase_x000D_ inhibitors. Chem Soc Rev. 2013 May 21;42(10):4459-75._x000D_ _x000D_ 5: García-García A, Ceballos-Laita L, Serna S, Artschwager R, Reichardt NC,_x000D_ Corzana F, Hurtado-Guerrero R. Structural basis for substrate specificity and_x000D_ catalysis of α1,6-fucosyltransferase. Nat Commun. 2020 Feb 20;11(1):973._x000D_ _x000D_ 6: Vodovar N, Schweisguth F. Functions of O-fucosyltransferase in Notch_x000D_ trafficking and signaling: towards the end of a controversy? J Biol._x000D_ 2008;7(2):7._x000D_ _x000D_ 7: Strecker C, Baerenfaenger M, Miehe M, Spillner E, Meyer B. In Silico_x000D_ Evaluation of the Binding Site of Fucosyltransferase 8 and First Attempts to_x000D_ Synthesize an Inhibitor with Drug-Like Properties. Chembiochem. 2020 Jul_x000D_ 1;21(13):1923-1931._x000D_ _x000D_ 8: Järvå MA, Dramicanin M, Lingford JP, Mao R, John A, Jarman KE, Grinter R,_x000D_ Goddard-Borger ED. Structural basis of substrate recognition and catalysis by_x000D_ fucosyltransferase 8. J Biol Chem. 2020 May 8;295(19):6677-6688._x000D_ _x000D_ 9: Boruah BM, Kadirvelraj R, Liu L, Ramiah A, Li C, Zong G, Bosman GP, Yang JY,_x000D_ Wang LX, Boons GJ, Wood ZA, Moremen KW. Characterizing human_x000D_ α-1,6-fucosyltransferase (FUT8) substrate specificity and structural_x000D_ similarities with related fucosyltransferases. J Biol Chem. 2020 Dec_x000D_ 11;295(50):17027-17045._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31633018/">10: Tan Y, Zhang Y, Han Y, Liu H, Chen H, Ma F, Withers SG, Feng Y, Yang G._x000D_ Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-_x000D_ throughput screening method. Sci Adv. 2019 Oct 9;5(10):eaaw8451. </a>_x000D_ _x000D_ <strong>Products Related to GnGn-bi-Asn-PABA</strong> <a href="https://moleculardepot.com/product-category/Carbohydrates/">: Carbohydrates</a>