TC-1698 (dihydrochloride)

TC-1698 dihydrochloride is a selective α7 nicotinic acetylcholine receptors agonist with EC50 value of 0.16 μM and 0.46 μM for monkey α7 nicotinic receptor and human α7 nicotinic receptor, respectively. TC-1698 dihydrochloride improves memory and has neuroprotective effects. TC-1698 dihydrochloride can be used for Alzheimer's disease research[1].

Product Specifications

CAS Number

[787587-06-8]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tc-1698-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

N1(CC2)C(C3=CC=CN=C3)CCC2CC1.Cl.Cl

Molecular Formula

C13H20Cl2N2

Molecular Weight

275.22

References & Citations

[1]Mazurov AA, et al. Discovery and development of α7 nicotinic acetylcholine receptor modulators. J Med Chem. 2011 Dec 8;54 (23) :7943-61.|[2]Marrero MB, et al. The neuroprotective effect of 2- (3-pyridyl) -1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J Pharmacol Exp Ther. 2004 Apr;309 (1) :16-27.|[3]Papke RL, et al. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2005 Nov 7;524 (1-3) :11-8.