Immunoproteasome activator 1
Immunoproteasome activator 1 (compound A) is a selective immunoproteasome activator that increases the presentation of individual MHC-I–bound peptides by over 100-fold. Immunoproteasome activator 1 binds to the proteasome structural subunit PSMA1 and promotes the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes[1].
Product Specifications
CAS Number
901728-48-1
UNSPSC
12352211
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/immunoproteasome-activator-1.html
Purity
90.0
Smiles
O=C(C)C1=CC(NC(C2=CC3=C(C(CCCN4CCC5)=C4C5=C3)OC2=N)=O)=CC=C1
Molecular Formula
C24H23N3O3
Molecular Weight
401.46
References & Citations
[1]Rana PS, et al. Immunoproteasome activation expands the MHC class I immunopeptidome, unmasks neoantigens and enhances T-cell antimyeloma activity. Mol Cancer Ther. 2024 Aug 30.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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