HH0043
HH0043 (Compound 10f) is an orally active and potent SOS1 inhibitor, with IC50 value of 5.8 nM. HH0043 can be used for the research of cancer[1].
Product Specifications
CAS Number
2922069-42-7
UNSPSC
12352005
Target
Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hh0043.html
Smiles
CC(N(CC1)CCN1C2=CC(C(N[C@H](C)C3=CC=CC(C(F)F)=C3F)=CC=N4)=C4C=N2)=O
Molecular Formula
C23H24F3N5O
Molecular Weight
443.46
References & Citations
[1]Li D, et al. Lead Identification of Novel Naphthyridine Derivatives as Potent SOS1 Inhibitors. ACS Med Chem Lett. 2024 Jun 3;15 (6) :958-964.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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