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TAS2R14 agonist-2

TAS2R14 agonist-2 (compound 28.1) is a potent and selective TAS2R14 agonist with an EC50 value of 72 nM. TAS2R14 agonist-2 reveals marked selectivity over a panel of 24 non-bitter taste human G protein-coupled receptors. TAS2R14 agonist-2 can be used for the studies of asthma or chronic obstructive pulmonary disease[1].

Product Specifications

CAS Number

[2883007-69-8]

UNSPSC

12352005

Target

Taste Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tas2r14-agonist-2.html

Purity

99.91

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

FC(F)(C1=CC(C)=NC(NC2=C(C3=NN=NN3)C=CC=C2)=N1)F

Molecular Formula

C13H10F3N7

Molecular Weight

321.26

References & Citations

[1]Waterloo L, et al. Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14. J Med Chem. 2023 Mar 9;66 (5) :3499-3521.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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