Homatropine (methylbromide)

Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Product Specifications

CAS Number

[80-49-9]

Product Name Alternative

Homatropine methobromide

UNSPSC

12352005

Hazard Statement

H302

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Homatropine-methylbromide.html

Purity

98.0

Solubility

DMSO : ≥ 31 mg/mL|H2O : ≥ 100 mg/mL

Smiles

C[N+]1([C@@H]2C[C@@H](OC(C(O)C3=CC=CC=C3)=O)C[C@H]1CC2)C.[Br-]

Molecular Formula

C17H24BrNO3

Molecular Weight

370.28

Precautions

H302

References & Citations

[1]Sim MK et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study. Clin Exp Hypertens. 1993 Mar;15 (2) :409-21.|[2]Bryant SM et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2 (4) :156-9.|[3]Leung E et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol. 1982 May 7;80 (1) :11-7.