Cafestol (Standard)

Cafestol (Standard) is the analytical standard of Cafestol. This product is intended for research and analytical applications. Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell apoptosis and autophagy, which can be used in the study of cancer[1].

Product Specifications

CAS Number

[469-83-0]

UNSPSC

12352005

Target

AP-1; Apoptosis; Autophagy; COX; ERK; FAK; NF-κB; PGE synthase; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer; Endocrinology; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cafestol-standard.html

Smiles

C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C5=C(OC=C5)CC2)C[C@@]([C@](CO)(O)C4)([H])CC3

Molecular Formula

C20H28O3

Molecular Weight

316.43

References & Citations

[1]Shen T, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33 (1) :128-32.