Riviciclib hydrochloride
Product Specifications
UNSPSC Description
Riviciclib hydrochloride (P276-00) is a potent cyclin-dependent kinase (CDK) inhibitor, which inhibits CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively[1][2].
Riviciclib hydrochloride (P276-00) shows antitumor activity on cisplatin-resistant cells[3].
Target Antigen
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Riviciclib_hydrochloride.html
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Smiles
[H]Cl.O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@@H]4CCN(C)[C@H]4CO)C(O)=CC(O)=C31
Molecular Weight
438.307
References & Citations
[1]Roskoski R Jr,Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs.Pharmacol Res. 2016 May;107:249-275.|[2]Joshi KS, et al. In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00. Mol Cancer Ther. 2007 Mar;6(3):918-25.|[3]Joshi KS,et al. P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther. 2007 Mar;6(3):926-34.Elife. 2020 Dec 7;9:e61405.|Pharmaceuticals. 2024 Apr 29, 17(5), 569.|Int J Mol Sci. 2022 Feb 24;23(5):2493.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16559/Riviciclib-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16559/Riviciclib-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
920113-03-7
Available Sizes
Curated Selection
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